Methylfolate (5-MTHF) Capsules
SAME DAY DISPATCH if ordered by 2pm!
What goes in matters
Every ingredient and amount is stated plainly.
Named after the leaf it was found in
- normal blood formation
- reduction of tiredness and fatigue
- normal function of the immune system
- normal psychological function
- normal amino acid synthesis
Folate was first isolated from spinach leaves in 1941.
From folic acid to methylfolate
Folic acid is not the form of folate your body uses directly. Step through the conversions it goes through, and see where methylfolate joins the path.
Folic acid
Folic acid is the stable, synthetic form of vitamin B9 used in fortified foods and many supplements. It has to be converted before the body can use it.
DHF
The enzyme dihydrofolate reductase (DHFR) reduces folic acid to dihydrofolate. In people this first step can be slow.
THF
A second reduction by the same enzyme gives tetrahydrofolate, the backbone that carries one-carbon units around the cell.
5,10-methylene-THF
THF picks up a one-carbon unit, becoming 5,10-methylene-THF.
5-MTHF
The enzyme MTHFR converts it to 5-methyltetrahydrofolate, the main form of folate found in the blood. A methylfolate supplement provides this form directly.
Folate contributes to normal blood formation and to the reduction of tiredness and fatigue.
Explanatory pathway, not measured results. Speak to your GP or pharmacist before taking folate if you take medication.
Support that fits your life…
Pre‑conception planning
Early pregnancy support
Active folate for MTHFR variants
Did you know?
Support that fits your life...
These high-strength methylfolate capsules are designed to sit alongside your existing prenatal or conception routine, offering a simple, once‑daily active folate in a clean, vegan, UK‑made format for women who want effective support before and during pregnancy.
Frequently Asked Questions
Everything you need to know about Roundway Methylfolate (5-MTHF) Capsules 5000mcg, Active Folate Vitamin B9 | 60 Capsules
It is generally recommended to begin folate supplementation at least one month before trying to conceive and continue through early pregnancy, alongside advice from your healthcare professional.
Take one capsule daily with a glass of water, preferably with a meal. Try to take it at the same time each day to build a simple, consistent routine.
This product provides folate as 5‑MTHF (methylfolate), the bioactive form that does not require conversion by the MTHFR enzyme, making it a suitable choice for people concerned about common MTHFR polymorphisms.
Many women use methylfolate alongside a prenatal or multivitamin, but you should check the folate content of all products you take and speak with a healthcare professional to ensure your total daily intake is appropriate for your individual needs.
Microcrystalline Cellulose, Capsule Shell: Hydroxypropyl Methylcellulose, L-5-Methyltetrahydrofolate Calcium, Plant-Based Anti-Caking Agent: Magnesium Stearate.
Ready when you are.
Free UK delivery over £50 · 60-day money-back guarantee
